ABSTRACT
[Objective] To elucidate the effects and mechanism of Naoqingling Decoction(ND)on Gilles de la Tourette syndrome(TS).[Method] Central nervous system of mice was stimulated by amphetamine(AMP)to develop the model of experimental tourette syndrome(ETS).Then we observed the stereotypia and autonomic activities of mice,and determined the levels of monoamine neurotransmitters such as dopamine(DA),norepinephrine(NE),5-hydroxytryptamine(5-HT)and 5-hydroxyindoleacetic acid(5-HIAA)in the brains.[Result] To compare with model group,three-dose ND groups can resist the determinate activities stimulated by AMP;can obviously decrease the autonomic activities of mice and degrade the levels of DA,NE,5-HT and 5-HIAA in the corpora striates.[Conclusion] ND has therapeutical effect on ETS model and it's mechanism may be its effects on the secretion or metabolism of neurotransmitter in the brains.
ABSTRACT
It didn't spread extensively whenInner Canon of Huangdi(Huangdi Nei Jing) was published.But the emperor in Song Dynasty attached importance to medicine and commanded the publishing bureau of correcting medical books to collate and publishPlain Questions(Su Wen).It was regarded as the teaching material of Imperial physician bureau.Inner Canon of Huangdi(Huangdi Nei Jing) was published in a large amount after the progress of printing technology.It impelled the book to be quite popular and spreading.The people studying on it increased day by day.It had a far-reaching impact on the development of medicine in later ages.